15 Haziran 2017 Perşembe

HOW DRUGS WORK

HOW DRUGS Function: RECEPTORS


Drugs work by appending to a specific atom called a receptor. A wide range of particles can be receptors for medications. Proteins on the surface of a cell that ordinarily react to hormones circling in the blood, catalysts that control the stream of vitality in a cell, even structures like the minute tubes (microtubules) that give the cell its shape can all be receptors. They can happen anyplace in the body: mind, heart, bone, skin.

A medication can influence any substantial capacity in the event that it can tie to some component of the cell that impacts that capacity.

At the point when a medication ties to its receptor and enacts it, the medication is called an agonist. This implies the medication has an impact. A few medications connect to a receptor and don't actuate it yet shield different atoms from getting to the receptor—regularly the particle that typically would be invigorating it. These medications are opponents. They act by keeping ordinary procedures from happening. A number of the psychoactive medications we have talked about in this book work by keeping the activity of typical neurotransmitters.

The poisons utilized as a part of toxic substance darts give a striking case. One dynamic compound in these toxic substances, curare, keeps the neurotransmitter acetyl‑choline from dealing with its receptor. Acetylcholine is important to trans­mit from mind to muscle the data that grants muscle withdrawal. \Arhen curare hinders the activity of acetylcholine, the muscles are deadened and the dash's casualty kicks the bucket from loss of motion of the muscles in charge of relaxing.

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